I'd like to think that SFSTL would get a new hyper (whether it be a Giovanola, B&M, or Intamin), mostly for selfish "I want it to be near me" reasons. Actually, I think a Giovanola with a Titan/Goliath layout would fit in quite nicely and provide a contrast from Missouri's other hypercoaster (The one I never talk about ;) ). Although SFSTL appears to have room for much expansion, the Giovanola's take up a relatively small footprint (for a hyper) and leave a lot of room for further development.
I loved Goliath when I was fortunate enough to visit SFMM last summer. While I don't think it's as good as the other two hypers I've ridden (Mamba and Magnum), it's extremely unique, silky smooth, and a positive G-fest. The coaster ran three train operation perfectly the day I visited, and I've never heard reliability issues before this post (maybe I'm in the dark). I don't see how one of these can be a bad addition to any park.
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Mamba--One of the Tallest, Longest, Fastest Roller Coasters in the World
Adam Rentchler