Not only PKI, and SFO, but you need to add Kennywood to your trip.
Here is how I did it last year.
Flew into Columbus, stayed in a cheap Days Inn.
Drove to PKI in morning, park was Great.
Drove back to Columbus and stayed in same Hotel.
Drove to Kennywood in Morning, park was Great.
Stayed in a cheap Days Inn outside of Pittsburgh.
Drove to SFO, stayed until 2pm.
Drove to CP, did the twilight rate after 4pm.
Stayed at Days Inn.
CP next day, 2nd train on MF.
Stayed at Days Inn.
Drove back to Columbus next day, flew home.
You can do the same thing. Most of the driving is done in the morning, and you arrive at the parks first thing, no crowds. Make your hotel reservations on the internet before you go.
All 4 parks are worth seeing, each one has unique features that make them great.