I'd go to SFO first, just so you're not let down after riding MF. ;) Seriously, because of your location, you'll want to keep your indirect driving for last. Go to SFO first up I-71 to I-271, exiting Rockside Rd. (looks like I-480 west) to SR 422 and follow the signs east.
From that area, you have to do a little back-and-forth up I-271 to get to I-480 west, as there is no direct way when not on the freeway. I-480 west to a short jog on the Turnpike west, to SR 57 north. Go the long block north on SR 57 past midway mall and pickup SR 2 west. Follow the signs frome there.
Your way home is going to suck, because you're smack dab in the middle of the two freeways that'll get you home. I think (without looking at a map) that I-75 would be closer to the west. You could take state routes, but I don't know if that would be faster or just slow you down.
-------------
Jeff
Webmaster/Admin - CoasterBuzz.com